El papel de la neuroplasticidad en las enfermedades neurodegenerativas

Autores/as

Palabras clave:

Neuroplasticidad, enfermedades neurodegenerativas

Resumen

Actualmente las enfermedades neurodegenerativas más comunes son Alzheimer, Parkinson, Huntington y Esclerosis lateral amiotrófica, afectan cerca de un 15% de la población global. La neuroplasticidad es la capacidad del cerebro de transformarse cuando se expone a diversos estímulos. El presente estudio consta en una revisión narrativa de tipo cualitativo en donde se recopilaron y sintetizaron artículos no mayores a 5 años, los resultados mostraron que la neuroplasticidad actúa con mayor eficacia en los estadios tempranos, sin embargo, conforme a degeneración progresa, la neuroplasticidad es incapaz de compensar el daño.

Referencias

Alves, R., & Crestani, A. P. (2022). The times they are a-changin': a proposal on how brain flexibility goes beyond the obvious to include the concepts of "upward" and "downward" to neuroplasticity. Molecular Psychiatry, 28(3), 977–992. https://doi.org/10.1038/s41380-022-01931-x

Johansson, H., Hagströmer, M., Grooten, A., & Franzén, E. (2020). Exercise-Induced Neuroplasticity in Parkinson's Disease: A Metasynthesis of the Literature. Neural Plasticity, 2020, 1–15. https://doi.org/10.1155/2020/4835819

Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., Goethe, E., Stepan, J., Denker, V., & Kuhn, J. (2018). Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell, 23(1), 25–30. https://doi.org/10.1016/j.stem.2018.04.004

Dorszewska, J., Kozubski, W., Waleszczyk, W., Zabel, M., & Ong, K. (2020). Neuroplasticity in the Pathology of Neurodegenerative Diseases. Neural Plasticity, 2020, 1–2. https://doi.org/10.1155/2020/8846432

Mateos-Aparicio, P., & Rodríguez-Moreno, A. (2019). The Impact of Studying Brain Plasticity. Frontiers in Cellular Neuroscience, 13. https://doi.org/10.3389/fncel.2019.00066

Schaefers, A. T. U., & Teuchert-Noodt, G. (2013). Developmental neuroplasticity and the origin of neurodegenerative diseases. The World Journal of Biological Psychiatry, 1–13. https://doi.org/10.3109/15622975.2013.798583

Siponkovski, S., Martínez‐Molina, N., Kuusela, L., Laitinen, S., Holma, M., Ahlfors, M., Jordan, H., Roine, R. P., Sarajuuri, J., Koskinen, S., & Immonen, I. (2020). Music Therapy Enhances Executive Functions and Prefrontal Structural Neuroplasticity after Traumatic Brain Injury: Evidence from a Randomized Controlled Trial. Journal of Neurotrauma, 37(4), 618-634. https://doi.org/10.1089/neu.2019.6537

Mahalakshmi, B., Maurya, N., Lee, S.-D., & Kumar, V. B. (2020). Possible neuroprotective mechanisms of physical exercise in neurodegeneration. International Journal of Molecular Sciences, 21(16), 5895. https://doi.org/10.3390/ijms21165895

Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., Goethe, E., Stepan, J., Denker, V., & Kuhn, J. (2018). Human adult neurogenesis: Evidence and remaining questions. Cell Stem Cell, 23(1), 25–30. https://doi.org/10.1016/j.stem.2018.04.004

Mendez Colmenares, A., Voss, M. W., Fanning, J., Salerno, E. A., Gothe, N. P., Thomas, M. L., McAuley, E., Kramer, A. F., & Erickson, K. I. (2021). White matter plasticity in healthy older adults: The effects of aerobic exercise. NeuroImage, 239, 118305. https://doi.org/10.1016/j.neuroimage.2021.118305

Francesca, D., Sara, C., & Paola, -. (n.d.). The gut-brain connection: Exploring the influence of the gut microbiota on neuroplasticity and neurodevelopmental disorders

Trejo-Lopez, J. A., Yachnis, A. T., & Prokop, S. (2022). Neuropathology of Alzheimer's Disease. Neurotherapeutics, 19(1), 173-185. https://doi.org/10.1007/s13311-021-01146-y

Kumar, D., Sharma, A., & Sharma, L. (2020). A Comprehensive Review of Alzheimer's Association with Related Proteins: Pathological Role and Therapeutic Significance. Current Neuropharmacology, 18(8), 674-695. https://doi.org/10.2174/1570159X18666200203101828

Simon, D. K., Tanner, C. M., & Brundin, P. (2020). Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology. Clinics in Geriatric Medicine, 36(1), 1-12. https://doi.org/10.1016/j.cger.2019.08.002

Jiang, A., Handley, R. R., Lehnert, K., & Snell, R. G. (2023). From Pathogenesis to Therapeutics: A Review of 150 Years of Huntington's Disease Research. International Journal of Molecular Sciences, 24(16), 13021. https://doi.org/10.3390/ijms241613021

Zahra, W., Shaukat, A., Mehmood, K., & Anwar, S. (2020). The Global Economic Impact of Neurodegenerative Diseases: Opportunities and Challenges. In C. Keswani (Ed.), Bioeconomy for Sustainable Development (pp. 377-397). Springer. https://doi.org/10.1007/978-981-13-9431-7_17

Gaceta del Senado. (2016). Senado.gob.mx. https://www.senado.gob.mx/65/gaceta_del_senado/documento/62028

IMSS. (2017, June 18). Incrementan Enfermedades Neurodegenerativas; Hay que Detectarlas a Tiempo, Recomienda el IMSS. Imss.gob.mx. http://www.imss.gob.mx/prensa/archivo/201706/180

IMSS. (n.d.). La punta del iceberg. Gob.Mx. https://www.gob.mx/imss/articulos/la-punta-del-iceberg?idiom=es

Congreso de la CDMX. (2022). https://www.congresocdmx.gob.mx/media/documentos/39f9ee1af210eaba1301c196e31dc203936569df.pdf

Instituto Nacional de Salud Pública. (s.f.). 10 de octubre, Día Mundial de la Salud Mental. https://www.insp.mx/avisos/10-de-octubre-dia-mundial-de-la-salud-mental

Feigin, V. L., Vos, T., & Nichols, E. (2020). Global burden of neurological disorders: Translating evidence into policy. The Lancet Neurology, 19(3), 255-265. https://doi.org/10.1016/S1474-4422(19)30411-9

Puderbaugh, M., & Emmady, P. D. (2023). Neuroplasticity. En StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK557811/

Admin. (2019, septiembre 18). Padecen alzhéimer unas 800 mil personas en México. Gaceta UNAM. https://www.gaceta.unam.mx/padecen-alzheimer-unas-800-mil-personas-en-mexico/

Instituto Nacional de Salud Pública. (s.f.). Hablemos de demencia. https://www.insp.mx/avisos/hablemos-de-demencia

Feigin, V. L., Vos, T., & Nichols, E. (2020). Global burden of neurological disorders: Translating evidence into policy. The Lancet Neurology, 19(3), 255-265. https://doi.org/10.1016/S1474-4422(19)30411-9

Tik, M., Woletz, M., Schuler, A. L., Vasileiadi, M., Cash, R. F. H., Zalesky, A., Yeh, P., & Loo, C. (2023). Acute TMS/fMRI response explains offline TMS network effects – An interleaved TMS-fMRI study. NeuroImage, 267, 119833. https://doi.org/10.1016/j.neuroimage.2022.119833

Descargas

Publicado

2024-08-22